Colchicine belongs to a group of alkaloids produced from the plant called colchicum autumnale. It is a prescription oral drug that is available in the tablet form. Colchicine serves an effective gouty arthritis treatment that can be used either alone or in a combination with other remedies.
Gout is the condition that provokes attacks of painful joint inflammations that occurrs due to an increased level of uric acid in your blood. Occasionally, the levels of urate can become too high, forming grit-like crystals in tendons and joints that trigger pain, swelling and inflammation. Traditionally, anti-inflammatory pain relievers are used for this condition, though not all the patients can use such a medication. Colchicine is an optional treatment for people who are contraindicated for anti-inflammatory drugs. The alternative medication works by decreasing the amount of white blood cells that move into inflamed zones. Such an action stops the inflammation cycle reducing pain and swelling.
Colchicine: Mechanism of Action
Being classified as a beta-tubulin interactor and anti-gout remedy, Colchicine is approved to be a safe and effective treatment of gout symptoms. It is proved by its ability to resist neutrophil-mediated inflammatory responses caused by monosodium crystals of uric acid in synovial fluid. The positive action of Colchicine starts when it disrupts B-tubulin polymerization, prevents degranulation, activation and migration of neutrophils to inflamed areas.
Possible Colchicine Interactions with Other Pharmaceuticals
Considering the drastic impact of Colchicine on the organism and its functioning, it is inevitable to consult a healthcare professional before its use. The medication can be administered in a combination with other gout drugs for a faster and better condition treatment. However, Colchicine can interact with numerous pharmaceuticals causing undesirable and harmful side effects. Thus, talk to your doctor to add effective, but not harmful drugs to the treatment course. Some treatments used together with Colchicine may change the route of its action, its effect on the organism or even activate dangerous side effects. To prevent such issues, one should not take Colchicine simultaneously with:
- Antibiotics and antifungals, as it significantly increases your colchicine level in the body leading to muscle damage;
- HIV/AIDS treatments;
- High cholesterol remedies;
- Heart medications;
- Anti-arrhythmic treatments and others.
Colchicine Side Effects and Misuse Issues
Proper Colchicine intake will help you treat gout and improve devastating symptoms of its attacks. Nevertheless, the smallest drug misuse can trigger undesirable reactions and other negative consequences. For example, Colchicine 0.5 mg tablet is completely safe and promotes the desirable effect, but, when it is used with other medication it can cause severe complications. Thus, call your doctor the moment you have noticed any side effects, especially:
- Allergic reactions;
- Nausea, diarrhea, vomiting;
- Muscle tenderness or pain;
- Fatigue and weariness;
- Easy bruising and unusual bleeding, etc.